The Middle East and North Africa Diagnosis and Management Guidelines for Inborn Errors of Immunity

Safa Baris; Hassan Abolhassani; Michel J. Massaad; Maryam Al-Nesf; Zahra Chavoshzadeh; Sevgi Keles; Ismail Reisli; Azzeddine Tahiat; Hiba Mohammad Shendi; Dalia Abd Elaziz; Brahim Belaid; Fatima Al Dhaheri; Sule Haskologlu; Figen Dogu; Imen Ben-Mustapha; Ali Sobh; Nermeen Galal; Safa Meshaal; Rabab Elhawary; Aisha El-marsafy; Fayhan J. Alroqi; Bandar Al-Saud; Mona Al-Ahmad; Tariq Al Farsi; Nashat AL Sukaiti; Salem Al-Tamemi; Cybel Mehawej; Ghassan Dbaibo; Gehad ElGhazali; Sara Sebnem Kilic; Ferah Genel; Ayca Kiykim; Ugur Musabak; Hasibe Artac; Sukru Nail Guner; Rachida Boukari; Reda Djidjik; Nadia Kechout; Deniz Cagdas; Zeinab Awad El-Sayed; Elif Karakoc-Aydiner; Raed Alzyoud; Mohamed Ridha Barbouche; Mehdi Adeli; Rima Hanna Wakim; Shereen M. Reda; Aydan Ikinciogullari; Ahmet Ozen; Aziz Bousfiha; Hamoud Al-Mousa; Nima Rezaei; Waleed Al-Herz; Raif S. Geha

doi:10.1016/j.jaip.2022.10.003

The Middle East and North Africa Diagnosis and Management Guidelines for Inborn Errors of Immunity

Safa Baris
, Hassan Abolhassani
, Michel J. Massaad
, Maryam Al-Nesf
, Zahra Chavoshzadeh
, Sevgi Keles
, Ismail Reisli
, Azzeddine Tahiat
, Hiba Mohammad Shendi
, Dalia Abd Elaziz
, Brahim Belaid
, Fatima Al Dhaheri
, Sule Haskologlu
, Figen Dogu
, Imen Ben-Mustapha
, Ali Sobh
, Nermeen Galal
, Safa Meshaal
, Rabab Elhawary
, Aisha El-marsafy

Fayhan J. Alroqi, Bandar Al-Saud, Mona Al-Ahmad, Tariq Al Farsi, Nashat AL Sukaiti, Salem Al-Tamemi, Cybel Mehawej, Ghassan Dbaibo, Gehad ElGhazali, Sara Sebnem Kilic, Ferah Genel, Ayca Kiykim, Ugur Musabak, Hasibe Artac, Sukru Nail Guner, Rachida Boukari, Reda Djidjik, Nadia Kechout, Deniz Cagdas, Zeinab Awad El-Sayed, Elif Karakoc-Aydiner, Raed Alzyoud, Mohamed Ridha Barbouche, Mehdi Adeli, Rima Hanna Wakim, Shereen M. Reda, Aydan Ikinciogullari, Ahmet Ozen, Aziz Bousfiha, Hamoud Al-Mousa, Nima Rezaei, Waleed Al-Herz, Raif S. Geha

Marmara University
Istanbul Jeffrey Modell Foundation Diagnostic Center for Primary Immune Deficiencies
Tehran University of Medical Sciences
Karolinska Institutet
American University of Beirut
Hamad Medical Corporation
Shahid Beheshti University of Medical Sciences
Necmettin Erbakan University
University of Algiers Benyoucef Benkhedda
Cairo University
Beni Messous University Hospital Center
Ankara University
Université de Tunis El Manar
Mansoura University
King Saud bin Abdulaziz University for Health Sciences
King Faisal Specialist Hospital and Research Centre
Alfaisal University
Kuwait University
Royal Hospital Oman
Sultan Qaboos University
Lebanese American University
Uludag University
Dr. Behçet Uz Children's Hospital
Istanbul University Cerrahpaşa
Baskent University
Selcuk University
Pasteur Institute of Algeria
Hacettepe University
Ain Shams University
Royal Medical Services
Sidra Medicine
University of Hassan II Casablanca
Universal Scientific Education and Research Network (USERN)
Al-Sabah Hospital
Boston Children's Hospital

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

Human inborn errors of immunity (IEI) are a group of 485 distinct genetic disorders affecting children and adults. Signs and symptoms of IEI are heterogeneous, and accurate diagnosis can be challenging and depends on the available human expertise and laboratory resources. The Middle East and North Africa (MENA) region has an increased prevalence of IEI because of the high rate of consanguinity with a predominance of autosomal recessive disorders. This area also exhibits more severe disease phenotypes compared with other regions, probably due to the delay in diagnosis. The MENA-IEI registry network has designed protocols and guidelines for the diagnosis and treatment of IEI, taking into consideration the variable regional expertise and resources. These guidelines are primarily meant to improve the care of patients within the region, but can also be followed in other regions with similar patient populations.

Original language	English
Pages (from-to)	158-180.e11
Journal	Journal of Allergy and Clinical Immunology: In Practice
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/j.jaip.2022.10.003
State	Published - Jan 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Diagnosis
Inborn errors of immunity
MENA region
Primary immunodeficiency
Treatment

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10.1016/j.jaip.2022.10.003

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Baris, S., Abolhassani, H., Massaad, M. J., Al-Nesf, M., Chavoshzadeh, Z., Keles, S., Reisli, I., Tahiat, A., Shendi, H. M., Elaziz, D. A., Belaid, B., Al Dhaheri, F., Haskologlu, S., Dogu, F., Ben-Mustapha, I., Sobh, A., Galal, N., Meshaal, S., Elhawary, R., ... Geha, R. S. (2023). The Middle East and North Africa Diagnosis and Management Guidelines for Inborn Errors of Immunity. Journal of Allergy and Clinical Immunology: In Practice, 11(1), 158-180.e11. https://doi.org/10.1016/j.jaip.2022.10.003

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title = "The Middle East and North Africa Diagnosis and Management Guidelines for Inborn Errors of Immunity",

abstract = "Human inborn errors of immunity (IEI) are a group of 485 distinct genetic disorders affecting children and adults. Signs and symptoms of IEI are heterogeneous, and accurate diagnosis can be challenging and depends on the available human expertise and laboratory resources. The Middle East and North Africa (MENA) region has an increased prevalence of IEI because of the high rate of consanguinity with a predominance of autosomal recessive disorders. This area also exhibits more severe disease phenotypes compared with other regions, probably due to the delay in diagnosis. The MENA-IEI registry network has designed protocols and guidelines for the diagnosis and treatment of IEI, taking into consideration the variable regional expertise and resources. These guidelines are primarily meant to improve the care of patients within the region, but can also be followed in other regions with similar patient populations.",

keywords = "Diagnosis, Inborn errors of immunity, MENA region, Primary immunodeficiency, Treatment",

author = "Safa Baris and Hassan Abolhassani and Massaad, \{Michel J.\} and Maryam Al-Nesf and Zahra Chavoshzadeh and Sevgi Keles and Ismail Reisli and Azzeddine Tahiat and Shendi, \{Hiba Mohammad\} and Elaziz, \{Dalia Abd\} and Brahim Belaid and \{Al Dhaheri\}, Fatima and Sule Haskologlu and Figen Dogu and Imen Ben-Mustapha and Ali Sobh and Nermeen Galal and Safa Meshaal and Rabab Elhawary and Aisha El-marsafy and Alroqi, \{Fayhan J.\} and Bandar Al-Saud and Mona Al-Ahmad and \{Al Farsi\}, Tariq and \{AL Sukaiti\}, Nashat and Salem Al-Tamemi and Cybel Mehawej and Ghassan Dbaibo and Gehad ElGhazali and Kilic, \{Sara Sebnem\} and Ferah Genel and Ayca Kiykim and Ugur Musabak and Hasibe Artac and Guner, \{Sukru Nail\} and Rachida Boukari and Reda Djidjik and Nadia Kechout and Deniz Cagdas and El-Sayed, \{Zeinab Awad\} and Elif Karakoc-Aydiner and Raed Alzyoud and Barbouche, \{Mohamed Ridha\} and Mehdi Adeli and Wakim, \{Rima Hanna\} and Reda, \{Shereen M.\} and Aydan Ikinciogullari and Ahmet Ozen and Aziz Bousfiha and Hamoud Al-Mousa and Nima Rezaei and Waleed Al-Herz and Geha, \{Raif S.\}",

note = "Publisher Copyright: {\textcopyright} 2022 American Academy of Allergy, Asthma \& Immunology",

year = "2023",

month = jan,

doi = "10.1016/j.jaip.2022.10.003",

language = "English",

volume = "11",

pages = "158--180.e11",

journal = "Journal of Allergy and Clinical Immunology: In Practice",

issn = "2213-2198",

publisher = "American Academy of Allergy, Asthma and Immunology",

number = "1",

}

Baris, S, Abolhassani, H, Massaad, MJ, Al-Nesf, M, Chavoshzadeh, Z, Keles, S, Reisli, I, Tahiat, A, Shendi, HM, Elaziz, DA, Belaid, B, Al Dhaheri, F, Haskologlu, S, Dogu, F, Ben-Mustapha, I, Sobh, A, Galal, N, Meshaal, S, Elhawary, R, El-marsafy, A, Alroqi, FJ, Al-Saud, B, Al-Ahmad, M, Al Farsi, T, AL Sukaiti, N, Al-Tamemi, S, Mehawej, C, Dbaibo, G, ElGhazali, G, Kilic, SS, Genel, F, Kiykim, A, Musabak, U, Artac, H, Guner, SN, Boukari, R, Djidjik, R, Kechout, N, Cagdas, D, El-Sayed, ZA, Karakoc-Aydiner, E, Alzyoud, R, Barbouche, MR, Adeli, M, Wakim, RH, Reda, SM, Ikinciogullari, A, Ozen, A, Bousfiha, A, Al-Mousa, H, Rezaei, N, Al-Herz, W & Geha, RS 2023, 'The Middle East and North Africa Diagnosis and Management Guidelines for Inborn Errors of Immunity', Journal of Allergy and Clinical Immunology: In Practice, vol. 11, no. 1, pp. 158-180.e11. https://doi.org/10.1016/j.jaip.2022.10.003

TY - JOUR

T1 - The Middle East and North Africa Diagnosis and Management Guidelines for Inborn Errors of Immunity

AU - Baris, Safa

AU - Abolhassani, Hassan

AU - Massaad, Michel J.

AU - Al-Nesf, Maryam

AU - Chavoshzadeh, Zahra

AU - Keles, Sevgi

AU - Reisli, Ismail

AU - Tahiat, Azzeddine

AU - Shendi, Hiba Mohammad

AU - Elaziz, Dalia Abd

AU - Belaid, Brahim

AU - Al Dhaheri, Fatima

AU - Haskologlu, Sule

AU - Dogu, Figen

AU - Ben-Mustapha, Imen

AU - Sobh, Ali

AU - Galal, Nermeen

AU - Meshaal, Safa

AU - Elhawary, Rabab

AU - El-marsafy, Aisha

AU - Alroqi, Fayhan J.

AU - Al-Saud, Bandar

AU - Al-Ahmad, Mona

AU - Al Farsi, Tariq

AU - AL Sukaiti, Nashat

AU - Al-Tamemi, Salem

AU - Mehawej, Cybel

AU - Dbaibo, Ghassan

AU - ElGhazali, Gehad

AU - Kilic, Sara Sebnem

AU - Genel, Ferah

AU - Kiykim, Ayca

AU - Musabak, Ugur

AU - Artac, Hasibe

AU - Guner, Sukru Nail

AU - Boukari, Rachida

AU - Djidjik, Reda

AU - Kechout, Nadia

AU - Cagdas, Deniz

AU - El-Sayed, Zeinab Awad

AU - Karakoc-Aydiner, Elif

AU - Alzyoud, Raed

AU - Barbouche, Mohamed Ridha

AU - Adeli, Mehdi

AU - Wakim, Rima Hanna

AU - Reda, Shereen M.

AU - Ikinciogullari, Aydan

AU - Ozen, Ahmet

AU - Bousfiha, Aziz

AU - Al-Mousa, Hamoud

AU - Rezaei, Nima

AU - Al-Herz, Waleed

AU - Geha, Raif S.

PY - 2023/1

Y1 - 2023/1

N2 - Human inborn errors of immunity (IEI) are a group of 485 distinct genetic disorders affecting children and adults. Signs and symptoms of IEI are heterogeneous, and accurate diagnosis can be challenging and depends on the available human expertise and laboratory resources. The Middle East and North Africa (MENA) region has an increased prevalence of IEI because of the high rate of consanguinity with a predominance of autosomal recessive disorders. This area also exhibits more severe disease phenotypes compared with other regions, probably due to the delay in diagnosis. The MENA-IEI registry network has designed protocols and guidelines for the diagnosis and treatment of IEI, taking into consideration the variable regional expertise and resources. These guidelines are primarily meant to improve the care of patients within the region, but can also be followed in other regions with similar patient populations.

AB - Human inborn errors of immunity (IEI) are a group of 485 distinct genetic disorders affecting children and adults. Signs and symptoms of IEI are heterogeneous, and accurate diagnosis can be challenging and depends on the available human expertise and laboratory resources. The Middle East and North Africa (MENA) region has an increased prevalence of IEI because of the high rate of consanguinity with a predominance of autosomal recessive disorders. This area also exhibits more severe disease phenotypes compared with other regions, probably due to the delay in diagnosis. The MENA-IEI registry network has designed protocols and guidelines for the diagnosis and treatment of IEI, taking into consideration the variable regional expertise and resources. These guidelines are primarily meant to improve the care of patients within the region, but can also be followed in other regions with similar patient populations.

KW - Diagnosis

KW - Inborn errors of immunity

KW - MENA region

KW - Primary immunodeficiency

KW - Treatment

UR - https://www.scopus.com/pages/publications/85141459623

U2 - 10.1016/j.jaip.2022.10.003

DO - 10.1016/j.jaip.2022.10.003

M3 - Review article

C2 - 36265766

AN - SCOPUS:85141459623

SN - 2213-2198

VL - 11

SP - 158-180.e11

JO - Journal of Allergy and Clinical Immunology: In Practice

JF - Journal of Allergy and Clinical Immunology: In Practice

IS - 1

ER -

The Middle East and North Africa Diagnosis and Management Guidelines for Inborn Errors of Immunity

Abstract

UN SDGs

Keywords

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