The Effect of Bariatric Surgery on PAI-1 Levels: A Systematic Review and Meta-analysis

Tannaz Jamialahamdi; Elaheh Mirhadi; Wael Almahmeed; Vasily N. Sukhorukov; Ali H. Eid; Sepideh Salehabadi; Amirhossein Sahebkar

doi:10.1007/s11695-024-07473-1

The Effect of Bariatric Surgery on PAI-1 Levels: A Systematic Review and Meta-analysis

Tannaz Jamialahamdi
, Elaheh Mirhadi
, Wael Almahmeed
, Vasily N. Sukhorukov
, Ali H. Eid
, Sepideh Salehabadi
, Amirhossein Sahebkar

Cleveland Clinic Abu Dhabi

Mashhad University of Medical Sciences
Russian Academy of Medical Sciences
Qatar University
Saveetha Institute of Medical and Technical Sciences (Deemed to be University)

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

The purpose of this meta-analysis was to determine the effect of bariatric surgery on circulating PAI-1. The meta-analysis was provided by comprehensive meta-analysis (CMA) V4 software. Meta-analysis of 33 studies showed a significant decrease in circulating PAI-1 after bariatric surgery (p < 0.001). A significant reduction was observed for two types of surgery) (p < 0.001 for LSG and p < 0.001 for RYGB). Furthermore, there was a significant change in circulating PAI-1 based on the follow-up duration (p < 0.001 for follow-up < 12 months and p < 0.001 for follow-up ≥ 12). We showed that bariatric surgery changed PAI-1 level significantly and changes in BMI after surgery were not related to PAI-1 alteration. Furthermore, this result was consistent based on follow-up duration and type of surgery.

Original language	English
Pages (from-to)	3876-3887
Number of pages	12
Journal	Obesity Surgery
Volume	34
Issue number	10
DOIs	https://doi.org/10.1007/s11695-024-07473-1
State	Published - Oct 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Fibrinolysis
Inflammation
Metabolic surgery
Obesity
PAI-1

Access to Document

10.1007/s11695-024-07473-1

Cite this

@article{a3a333d1f4794294aa43f6662e585bb8,

title = "The Effect of Bariatric Surgery on PAI-1 Levels: A Systematic Review and Meta-analysis",

abstract = "The purpose of this meta-analysis was to determine the effect of bariatric surgery on circulating PAI-1. The meta-analysis was provided by comprehensive meta-analysis (CMA) V4 software. Meta-analysis of 33 studies showed a significant decrease in circulating PAI-1 after bariatric surgery (p < 0.001). A significant reduction was observed for two types of surgery) (p < 0.001 for LSG and p < 0.001 for RYGB). Furthermore, there was a significant change in circulating PAI-1 based on the follow-up duration (p < 0.001 for follow-up < 12 months and p < 0.001 for follow-up ≥ 12). We showed that bariatric surgery changed PAI-1 level significantly and changes in BMI after surgery were not related to PAI-1 alteration. Furthermore, this result was consistent based on follow-up duration and type of surgery.",

keywords = "Fibrinolysis, Inflammation, Metabolic surgery, Obesity, PAI-1",

author = "Tannaz Jamialahamdi and Elaheh Mirhadi and Wael Almahmeed and Sukhorukov, \{Vasily N.\} and Eid, \{Ali H.\} and Sepideh Salehabadi and Amirhossein Sahebkar",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.",

year = "2024",

month = oct,

doi = "10.1007/s11695-024-07473-1",

language = "English",

volume = "34",

pages = "3876--3887",

journal = "Obesity Surgery",

issn = "0960-8923",

publisher = "Springer",

number = "10",

}

TY - JOUR

T1 - The Effect of Bariatric Surgery on PAI-1 Levels

T2 - A Systematic Review and Meta-analysis

AU - Jamialahamdi, Tannaz

AU - Mirhadi, Elaheh

AU - Almahmeed, Wael

AU - Sukhorukov, Vasily N.

AU - Eid, Ali H.

AU - Salehabadi, Sepideh

AU - Sahebkar, Amirhossein

N1 - Publisher Copyright: © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.

PY - 2024/10

Y1 - 2024/10

N2 - The purpose of this meta-analysis was to determine the effect of bariatric surgery on circulating PAI-1. The meta-analysis was provided by comprehensive meta-analysis (CMA) V4 software. Meta-analysis of 33 studies showed a significant decrease in circulating PAI-1 after bariatric surgery (p < 0.001). A significant reduction was observed for two types of surgery) (p < 0.001 for LSG and p < 0.001 for RYGB). Furthermore, there was a significant change in circulating PAI-1 based on the follow-up duration (p < 0.001 for follow-up < 12 months and p < 0.001 for follow-up ≥ 12). We showed that bariatric surgery changed PAI-1 level significantly and changes in BMI after surgery were not related to PAI-1 alteration. Furthermore, this result was consistent based on follow-up duration and type of surgery.

AB - The purpose of this meta-analysis was to determine the effect of bariatric surgery on circulating PAI-1. The meta-analysis was provided by comprehensive meta-analysis (CMA) V4 software. Meta-analysis of 33 studies showed a significant decrease in circulating PAI-1 after bariatric surgery (p < 0.001). A significant reduction was observed for two types of surgery) (p < 0.001 for LSG and p < 0.001 for RYGB). Furthermore, there was a significant change in circulating PAI-1 based on the follow-up duration (p < 0.001 for follow-up < 12 months and p < 0.001 for follow-up ≥ 12). We showed that bariatric surgery changed PAI-1 level significantly and changes in BMI after surgery were not related to PAI-1 alteration. Furthermore, this result was consistent based on follow-up duration and type of surgery.

KW - Fibrinolysis

KW - Inflammation

KW - Metabolic surgery

KW - Obesity

KW - PAI-1

UR - https://www.scopus.com/pages/publications/85202947411

U2 - 10.1007/s11695-024-07473-1

DO - 10.1007/s11695-024-07473-1

M3 - Review article

C2 - 39222193

AN - SCOPUS:85202947411

SN - 0960-8923

VL - 34

SP - 3876

EP - 3887

JO - Obesity Surgery

JF - Obesity Surgery

IS - 10

ER -

The Effect of Bariatric Surgery on PAI-1 Levels: A Systematic Review and Meta-analysis

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this