TY - GEN
T1 - Targeted Liposomes Production in a Microfluidic Chip
AU - Agam, Mohamed
AU - Paul, Vinod
AU - Abdelgawad, Mohamed
AU - Husseini, Ghaleb
N1 - Publisher Copyright:
© 2021 IEEE.
PY - 2021
Y1 - 2021
N2 - Liposomes are used and heavily researched in drug delivery. These nanocarriers encapsulate therapeutic agents efficiently and deliver their contents to tumors with minimal undesired side effects. In this study, we investigated the preparation of Estrone liposomes in a commercially available microfluidic chip (a Herringbone micromixer). Using this chip, we synthesized Estrone liposomes with high uniformity and reproducibility, contrary to conventional methods (e.g., the thin film hydration), which are cumbersome and non-reliable. In addition, we studied the effect of the lipids concentration and the flow rate ratio between the lipids stream and the aqueous stream on the size and polydispersity of the resulting liposomes. The smallest liposomes obtained were 91.8 ± 4.8nm in radius (mean ± SD) with a polydispersity of 17.2%.
AB - Liposomes are used and heavily researched in drug delivery. These nanocarriers encapsulate therapeutic agents efficiently and deliver their contents to tumors with minimal undesired side effects. In this study, we investigated the preparation of Estrone liposomes in a commercially available microfluidic chip (a Herringbone micromixer). Using this chip, we synthesized Estrone liposomes with high uniformity and reproducibility, contrary to conventional methods (e.g., the thin film hydration), which are cumbersome and non-reliable. In addition, we studied the effect of the lipids concentration and the flow rate ratio between the lipids stream and the aqueous stream on the size and polydispersity of the resulting liposomes. The smallest liposomes obtained were 91.8 ± 4.8nm in radius (mean ± SD) with a polydispersity of 17.2%.
UR - https://www.scopus.com/pages/publications/85130354026
U2 - 10.1109/NANOMED54179.2021.9766644
DO - 10.1109/NANOMED54179.2021.9766644
M3 - Conference contribution
AN - SCOPUS:85130354026
T3 - IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED
SP - 53
EP - 56
BT - Proceedings of the 15th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2021
PB - IEEE Computer Society
T2 - 15th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2021
Y2 - 15 November 2021 through 17 November 2021
ER -