Retinal Nerve Fibre Layer Thickness Increases with Decreasing Spectralis OCT Signal Strength in Normal Eyes

Margaret R. Strampe; Luai Eldweik; Benjamin C. Chaon; Sarah Maki; Tyler Wieland; Celine Satija; Collin McClelland; Michael S. Lee

doi:10.1080/01658107.2019.1653934

Retinal Nerve Fibre Layer Thickness Increases with Decreasing Spectralis OCT Signal Strength in Normal Eyes

Margaret R. Strampe
, Luai Eldweik
, Benjamin C. Chaon
, Sarah Maki
, Tyler Wieland
, Celine Satija
, Collin McClelland
, Michael S. Lee

Cleveland Clinic Abu Dhabi

University of Minnesota Twin Cities
Johns Hopkins University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We sought to determine effect of signal strength on mean retinal nerve fibre layer (RNFL) using Spectralis optical coherence tomography (S-OCT). Thirty normal subjects (18 female, mean 37.9 years, range 24-61) were imaged with S-OCT using variably dense Bangerter foils to alter Q value (1 unit signal strength = 4 units Q). We found a statistically significant (p < 0.01) linear relationship (R = 0.8643) between Q and RNFL (1 unit decrease Q = 0.181 um mean RNFL increase). Unlike previous observations of Cirrus and Stratus OCT, we found RNFL thickness does not decrease with decreasing signal strength in S-OCT.

Original language	English
Pages (from-to)	100-103
Number of pages	4
Journal	Neuro-Ophthalmology
Volume	44
Issue number	2
DOIs	https://doi.org/10.1080/01658107.2019.1653934
State	Published - 3 Mar 2020

Keywords

OCT
RNFL
Retinal nerve fiber layer
Spectralis
optical coherence tomography
signal strength

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10.1080/01658107.2019.1653934

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title = "Retinal Nerve Fibre Layer Thickness Increases with Decreasing Spectralis OCT Signal Strength in Normal Eyes",

abstract = "We sought to determine effect of signal strength on mean retinal nerve fibre layer (RNFL) using Spectralis optical coherence tomography (S-OCT). Thirty normal subjects (18 female, mean 37.9 years, range 24-61) were imaged with S-OCT using variably dense Bangerter foils to alter Q value (1 unit signal strength = 4 units Q). We found a statistically significant (p < 0.01) linear relationship (R = 0.8643) between Q and RNFL (1 unit decrease Q = 0.181 um mean RNFL increase). Unlike previous observations of Cirrus and Stratus OCT, we found RNFL thickness does not decrease with decreasing signal strength in S-OCT.",

keywords = "OCT, RNFL, Retinal nerve fiber layer, Spectralis, optical coherence tomography, signal strength",

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year = "2020",

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doi = "10.1080/01658107.2019.1653934",

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T1 - Retinal Nerve Fibre Layer Thickness Increases with Decreasing Spectralis OCT Signal Strength in Normal Eyes

AU - Strampe, Margaret R.

AU - Eldweik, Luai

AU - Chaon, Benjamin C.

AU - Maki, Sarah

AU - Wieland, Tyler

AU - Satija, Celine

AU - McClelland, Collin

AU - Lee, Michael S.

PY - 2020/3/3

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AB - We sought to determine effect of signal strength on mean retinal nerve fibre layer (RNFL) using Spectralis optical coherence tomography (S-OCT). Thirty normal subjects (18 female, mean 37.9 years, range 24-61) were imaged with S-OCT using variably dense Bangerter foils to alter Q value (1 unit signal strength = 4 units Q). We found a statistically significant (p < 0.01) linear relationship (R = 0.8643) between Q and RNFL (1 unit decrease Q = 0.181 um mean RNFL increase). Unlike previous observations of Cirrus and Stratus OCT, we found RNFL thickness does not decrease with decreasing signal strength in S-OCT.

KW - OCT

KW - RNFL

KW - Retinal nerve fiber layer

KW - Spectralis

KW - optical coherence tomography

KW - signal strength

UR - https://www.scopus.com/pages/publications/85074732578

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ER -

Retinal Nerve Fibre Layer Thickness Increases with Decreasing Spectralis OCT Signal Strength in Normal Eyes

Abstract

Keywords

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