Recent developments and advanced strategies for promoting burn wound healing

Wound healing is a highly specialized and intricate mechanism of substituting the damaged/injured tissues with the newer healthy tissues. Chronic wounds, particularly the burn wounds (BWs) present serious challenges to normal healing mechanism and hence require specialized biomedical intensive care. Owing to their intricate pathophysiology and risks of developing secondary complications (i.e., burn shock, intense pain, hypovolemia, immunosuppression, and severe local or systemic microbial infections), BWs management demands multipart therapeutic regimen in order to minimize morbidity and mortality. Though, various conventional approaches are being used for promoting BWs healing, but BWs demands more competitive therapies. In recent decades, nanotechnology-composited wound dressings have revolutionized BWs healing and tissue regeneration. These newer modalities not only promote wound healing but also eradicate risks of bacterial infection and avert serious secondary complications associated with immunosuppression. Therefore, in this review, we have summarized and conceptualized the available evidences about therapeutic dominance of nanotherapeutics for management of mild-to-severe BWs (i.e., first-, second-, third- and fourth-degree) with special focus on improving therapeutic outcomes, minimizing the side effects, improving the patient compliance and quality of life. Moreover, current challenges to nanotherapeutics as well as various remedial adaptations to mitigate these encounters have also been pondered.