Outcomes of caspofungin use in the treatment of Candida-related urinary tract infections, a case series

Laila Rkieh; Wasim S. El Nekidy; Leen Oyoun Alsoud; Adnan Alatoom; Rania El Lababidi; Mohamad Mooty; Ahmad R. Nusair

doi:10.1016/j.idcr.2022.e01510

Outcomes of caspofungin use in the treatment of Candida-related urinary tract infections, a case series

Trillium Health Partners
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
National Reference Laboratory
Marshall University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Echinocandins are generally excluded in the treatment of Candida-related urinary tract infections due to their poor urinary concentration. In the presence of fluconazole resistant Candida species, such as C. Glabrata and C. auris, alternative therapies are needed. We herein report the use of caspofungin for the treatment of 10 patients with candiduria, including C. auris. Mycological cure was achieved in 6 of 7 patients and clinical cure was achieved in 8 of 10 patients. Larger studies are needed to confirm our findings.

Original language	English
Article number	e01510
Journal	IDCases
Volume	28
DOIs	https://doi.org/10.1016/j.idcr.2022.e01510
State	Published - Jan 2022

Keywords

Candiduria
Caspofungin
Urinary tract infection

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10.1016/j.idcr.2022.e01510

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title = "Outcomes of caspofungin use in the treatment of Candida-related urinary tract infections, a case series",

abstract = "Echinocandins are generally excluded in the treatment of Candida-related urinary tract infections due to their poor urinary concentration. In the presence of fluconazole resistant Candida species, such as C. Glabrata and C. auris, alternative therapies are needed. We herein report the use of caspofungin for the treatment of 10 patients with candiduria, including C. auris. Mycological cure was achieved in 6 of 7 patients and clinical cure was achieved in 8 of 10 patients. Larger studies are needed to confirm our findings.",

keywords = "Candiduria, Caspofungin, Urinary tract infection",

author = "Laila Rkieh and \{El Nekidy\}, \{Wasim S.\} and Alsoud, \{Leen Oyoun\} and Adnan Alatoom and \{El Lababidi\}, Rania and Mohamad Mooty and Nusair, \{Ahmad R.\}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = jan,

doi = "10.1016/j.idcr.2022.e01510",

language = "English",

volume = "28",

journal = "IDCases",

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TY - JOUR

T1 - Outcomes of caspofungin use in the treatment of Candida-related urinary tract infections, a case series

AU - Rkieh, Laila

AU - El Nekidy, Wasim S.

AU - Alsoud, Leen Oyoun

AU - Alatoom, Adnan

AU - El Lababidi, Rania

AU - Mooty, Mohamad

AU - Nusair, Ahmad R.

PY - 2022/1

Y1 - 2022/1

N2 - Echinocandins are generally excluded in the treatment of Candida-related urinary tract infections due to their poor urinary concentration. In the presence of fluconazole resistant Candida species, such as C. Glabrata and C. auris, alternative therapies are needed. We herein report the use of caspofungin for the treatment of 10 patients with candiduria, including C. auris. Mycological cure was achieved in 6 of 7 patients and clinical cure was achieved in 8 of 10 patients. Larger studies are needed to confirm our findings.

AB - Echinocandins are generally excluded in the treatment of Candida-related urinary tract infections due to their poor urinary concentration. In the presence of fluconazole resistant Candida species, such as C. Glabrata and C. auris, alternative therapies are needed. We herein report the use of caspofungin for the treatment of 10 patients with candiduria, including C. auris. Mycological cure was achieved in 6 of 7 patients and clinical cure was achieved in 8 of 10 patients. Larger studies are needed to confirm our findings.

KW - Candiduria

KW - Caspofungin

KW - Urinary tract infection

UR - https://www.scopus.com/pages/publications/85130579541

U2 - 10.1016/j.idcr.2022.e01510

DO - 10.1016/j.idcr.2022.e01510

M3 - Article

AN - SCOPUS:85130579541

SN - 2214-2509

VL - 28

JO - IDCases

JF - IDCases

M1 - e01510

ER -

Outcomes of caspofungin use in the treatment of Candida-related urinary tract infections, a case series

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Keywords

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