Natural Products for Targeting Acanthamoeba spp.

Yassmin Isse Wehelie; Aishath Leesha Nasih; Ayaz Anwar; Ruqaiyyah Siddiqui; Sutherland Maciver; Naveed Ahmed Khan

doi:10.2174/2211352519666211119091316

Natural Products for Targeting Acanthamoeba spp.

Yassmin Isse Wehelie
, Aishath Leesha Nasih
, Ayaz Anwar
, Ruqaiyyah Siddiqui
, Sutherland Maciver
, Naveed Ahmed Khan

Sunway University
University of Edinburgh
University of Sharjah

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

Pathogenic Acanthamoeba is responsible for causing serious eye and fatal brain infections. A successful prognosis remains elusive despite advances in chemotherapeutics and supportive care. Natural products of medicinal value remain a promising source for drug development due to their broad-spectrum antimicrobial activities. Herein, we discuss anti-Acanthamoebic properties of natural products originating from plants, marine, and microbial sources that could be exploited as a potential avenue for drug discovery against infections caused by Acanthamoeba.

Original language	English
Article number	e191121198116
Pages (from-to)	21-33
Number of pages	13
Journal	Anti-Infective Agents
Volume	20
Issue number	3
DOIs	https://doi.org/10.2174/2211352519666211119091316
State	Published - Jun 2022

Keywords

Natural products
granulomatous amoebic encephalitis
keratitis
parasite
protozoa
treatment

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10.2174/2211352519666211119091316

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title = "Natural Products for Targeting Acanthamoeba spp.",

abstract = "Pathogenic Acanthamoeba is responsible for causing serious eye and fatal brain infections. A successful prognosis remains elusive despite advances in chemotherapeutics and supportive care. Natural products of medicinal value remain a promising source for drug development due to their broad-spectrum antimicrobial activities. Herein, we discuss anti-Acanthamoebic properties of natural products originating from plants, marine, and microbial sources that could be exploited as a potential avenue for drug discovery against infections caused by Acanthamoeba.",

keywords = "Natural products, granulomatous amoebic encephalitis, keratitis, parasite, protozoa, treatment",

author = "Wehelie, \{Yassmin Isse\} and Nasih, \{Aishath Leesha\} and Ayaz Anwar and Ruqaiyyah Siddiqui and Sutherland Maciver and Khan, \{Naveed Ahmed\}",

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year = "2022",

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doi = "10.2174/2211352519666211119091316",

language = "English",

volume = "20",

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journal = "Anti-Infective Agents",

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TY - JOUR

T1 - Natural Products for Targeting Acanthamoeba spp.

AU - Wehelie, Yassmin Isse

AU - Nasih, Aishath Leesha

AU - Anwar, Ayaz

AU - Siddiqui, Ruqaiyyah

AU - Maciver, Sutherland

AU - Khan, Naveed Ahmed

PY - 2022/6

Y1 - 2022/6

N2 - Pathogenic Acanthamoeba is responsible for causing serious eye and fatal brain infections. A successful prognosis remains elusive despite advances in chemotherapeutics and supportive care. Natural products of medicinal value remain a promising source for drug development due to their broad-spectrum antimicrobial activities. Herein, we discuss anti-Acanthamoebic properties of natural products originating from plants, marine, and microbial sources that could be exploited as a potential avenue for drug discovery against infections caused by Acanthamoeba.

AB - Pathogenic Acanthamoeba is responsible for causing serious eye and fatal brain infections. A successful prognosis remains elusive despite advances in chemotherapeutics and supportive care. Natural products of medicinal value remain a promising source for drug development due to their broad-spectrum antimicrobial activities. Herein, we discuss anti-Acanthamoebic properties of natural products originating from plants, marine, and microbial sources that could be exploited as a potential avenue for drug discovery against infections caused by Acanthamoeba.

KW - Natural products

KW - granulomatous amoebic encephalitis

KW - keratitis

KW - parasite

KW - protozoa

KW - treatment

UR - https://www.scopus.com/pages/publications/85132873726

U2 - 10.2174/2211352519666211119091316

DO - 10.2174/2211352519666211119091316

M3 - Short survey

AN - SCOPUS:85132873726

SN - 2211-3525

VL - 20

SP - 21

EP - 33

JO - Anti-Infective Agents

JF - Anti-Infective Agents

IS - 3

M1 - e191121198116

ER -

Natural Products for Targeting Acanthamoeba spp.

Abstract

Keywords

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