Hereditary pancreatic cancer

Derk C.F. Klatte; Michael B. Wallace; Matthias Löhr; Marco J. Bruno; Monique E. van Leerdam

doi:10.1016/j.bpg.2021.101783

Hereditary pancreatic cancer

Derk C.F. Klatte
, Michael B. Wallace
, Matthias Löhr
, Marco J. Bruno
, Monique E. van Leerdam

Leiden University
Mayo Clinic Rochester, MN
Karolinska Institutet
Erasmus University Rotterdam
Netherlands Cancer Institute

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

Pancreatic cancer is one of the deadliest malignancies. Therefore, there is an urgent need to detect pancreatic cancer in an earlier stage to improve outcomes. A variety of hereditary cancer syndromes have been associated with an increased risk of developing pancreatic cancer, and these individuals may benefit from surveillance programs. Surveillance programs have shown potential to improve outcomes, but have important risks such as overtreatment. In this review we will discuss the definitions and epidemiology of hereditary pancreatic cancer, recommendations for genetic testing and participation in surveillance. Important aspects are differences in surveillance strategies, target lesions, and potential benefits and harms of surveillance. Lastly we will highlight future directions for research and improvement of care for individuals at high-risk of pancreatic cancer.

Original language	English
Article number	101783
Journal	Bailliere's Best Practice and Research in Clinical Gastroenterology
Volume	58-59
DOIs	https://doi.org/10.1016/j.bpg.2021.101783
State	Published - 1 Jun 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Familial pancreatic cancer
Hereditary pancreatic cancer
High-risk individuals
Pancreatic ductal adenocarcinoma
Surveillance

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10.1016/j.bpg.2021.101783

Cite this

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title = "Hereditary pancreatic cancer",

abstract = "Pancreatic cancer is one of the deadliest malignancies. Therefore, there is an urgent need to detect pancreatic cancer in an earlier stage to improve outcomes. A variety of hereditary cancer syndromes have been associated with an increased risk of developing pancreatic cancer, and these individuals may benefit from surveillance programs. Surveillance programs have shown potential to improve outcomes, but have important risks such as overtreatment. In this review we will discuss the definitions and epidemiology of hereditary pancreatic cancer, recommendations for genetic testing and participation in surveillance. Important aspects are differences in surveillance strategies, target lesions, and potential benefits and harms of surveillance. Lastly we will highlight future directions for research and improvement of care for individuals at high-risk of pancreatic cancer.",

keywords = "Familial pancreatic cancer, Hereditary pancreatic cancer, High-risk individuals, Pancreatic ductal adenocarcinoma, Surveillance",

author = "Klatte, \{Derk C.F.\} and Wallace, \{Michael B.\} and Matthias L{\"o}hr and Bruno, \{Marco J.\} and \{van Leerdam\}, \{Monique E.\}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = jun,

day = "1",

doi = "10.1016/j.bpg.2021.101783",

language = "English",

volume = "58-59",

journal = "Bailliere's Best Practice and Research in Clinical Gastroenterology",

issn = "1521-6918",

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}

TY - JOUR

T1 - Hereditary pancreatic cancer

AU - Klatte, Derk C.F.

AU - Wallace, Michael B.

AU - Löhr, Matthias

AU - Bruno, Marco J.

AU - van Leerdam, Monique E.

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Pancreatic cancer is one of the deadliest malignancies. Therefore, there is an urgent need to detect pancreatic cancer in an earlier stage to improve outcomes. A variety of hereditary cancer syndromes have been associated with an increased risk of developing pancreatic cancer, and these individuals may benefit from surveillance programs. Surveillance programs have shown potential to improve outcomes, but have important risks such as overtreatment. In this review we will discuss the definitions and epidemiology of hereditary pancreatic cancer, recommendations for genetic testing and participation in surveillance. Important aspects are differences in surveillance strategies, target lesions, and potential benefits and harms of surveillance. Lastly we will highlight future directions for research and improvement of care for individuals at high-risk of pancreatic cancer.

AB - Pancreatic cancer is one of the deadliest malignancies. Therefore, there is an urgent need to detect pancreatic cancer in an earlier stage to improve outcomes. A variety of hereditary cancer syndromes have been associated with an increased risk of developing pancreatic cancer, and these individuals may benefit from surveillance programs. Surveillance programs have shown potential to improve outcomes, but have important risks such as overtreatment. In this review we will discuss the definitions and epidemiology of hereditary pancreatic cancer, recommendations for genetic testing and participation in surveillance. Important aspects are differences in surveillance strategies, target lesions, and potential benefits and harms of surveillance. Lastly we will highlight future directions for research and improvement of care for individuals at high-risk of pancreatic cancer.

KW - Familial pancreatic cancer

KW - Hereditary pancreatic cancer

KW - High-risk individuals

KW - Pancreatic ductal adenocarcinoma

KW - Surveillance

UR - https://www.scopus.com/pages/publications/85122234046

U2 - 10.1016/j.bpg.2021.101783

DO - 10.1016/j.bpg.2021.101783

M3 - Review article

C2 - 35988957

AN - SCOPUS:85122234046

SN - 1521-6918

VL - 58-59

JO - Bailliere's Best Practice and Research in Clinical Gastroenterology

JF - Bailliere's Best Practice and Research in Clinical Gastroenterology

M1 - 101783

ER -

Hereditary pancreatic cancer

Abstract

UN SDGs

Keywords

Access to Document

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