TY - JOUR
T1 - Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
AU - Global Sewage Surveillance Consortium
AU - Munk, Patrick
AU - Brinch, Christian
AU - Møller, Frederik Duus
AU - Petersen, Thomas N.
AU - Hendriksen, Rene S.
AU - Seyfarth, Anne Mette
AU - Kjeldgaard, Jette S.
AU - Svendsen, Christina Aaby
AU - van Bunnik, Bram
AU - Berglund, Fanny
AU - Bego, Artan
AU - Power, Pablo
AU - Rees, Catherine
AU - Lambrinidis, Dionisia
AU - Neilson, Elizabeth Heather Jakobsen
AU - Gibb, Karen
AU - Coventry, Kris
AU - Collignon, Peter
AU - Cassar, Susan
AU - Allerberger, Franz
AU - Begum, Anowara
AU - Hossain, Zenat Zebin
AU - Worrell, Carlon
AU - Vandenberg, Olivier
AU - Pieters, Ilse
AU - Victorien, Dougnon Tamègnon
AU - Gutierrez, Angela Daniela Salazar
AU - Soria, Freddy
AU - Grujić, Vesna Rudić
AU - Mazalica, Nataša
AU - Rahube, Teddie O.
AU - Tagliati, Carlos Alberto
AU - Rodrigues, Dalia
AU - Oliveira, Guilherme
AU - de Souza, Larissa Camila Ribeiro
AU - Ivanov, Ivan
AU - Juste, Bonkoungou Isidore
AU - Oumar, Traoré
AU - Sopheak, Thet
AU - Vuthy, Yith
AU - Ngandijo, Antoinette
AU - Nzouankeu, Ariane
AU - Olivier, Ziem A.Abah Jacques
AU - Yost, Christopher K.
AU - Kumar, Pratik
AU - Brar, Satinder Kaur
AU - Tabo, Djim Adjim
AU - Adell, Aiko D.
AU - Thomsen, Jens
AU - Jassim, Laila Mohamed
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.
AB - Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.
UR - https://www.scopus.com/pages/publications/85143185703
U2 - 10.1038/s41467-022-34312-7
DO - 10.1038/s41467-022-34312-7
M3 - Article
C2 - 36456547
AN - SCOPUS:85143185703
SN - 2041-1723
VL - 13
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 7251
ER -
SDG 11 Sustainable Cities and Communities