Disease of the Year 2025: Uveitis Masquerade Syndromes Neoplastic Masquerades in Adults

Zohar Habot-Wilner; Michael Ostrovsky; Ester Carreño; Laura Domínguez García; Sofia Androudi; Piergiorgio Neri; Sarah Touhami; Ines Leal

doi:10.1080/09273948.2025.2548944

Disease of the Year 2025: Uveitis Masquerade Syndromes Neoplastic Masquerades in Adults

Zohar Habot-Wilner
, Michael Ostrovsky
, Ester Carreño
, Laura Domínguez García
, Sofia Androudi
, Piergiorgio Neri
, Sarah Touhami
, Ines Leal

Tel Aviv University
Hebrew University of Jerusalem
Universidad Autónoma de Madrid
University of Thessaly
Case Western Reserve University
Sorbonne Université
University of Lisbon

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Ocular neoplastic masquerade syndromes in adults pose a significant diagnostic challenge, as intraocular malignancies can closely mimic inflammatory ocular diseases. This review focuses on intraocular lymphoma, including vitreoretinal lymphoma and uveal lymphoma, and on choroidal metastases. It provides a comprehensive overview of disease epidemiology, symptoms, clinical manifestations, imaging findings, diagnostic approach, the role of ancillary testing, and current management strategies. The importance of a multidisciplinary approach is emphasized. This review aims to provide clinicians with practical tools for diagnosing and managing neoplastic masquerade syndromes.

Original language	English
Pages (from-to)	211-223
Number of pages	13
Journal	Ocular Immunology and Inflammation
Volume	34
Issue number	2
DOIs	https://doi.org/10.1080/09273948.2025.2548944
State	Published - 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Choroidal metastasis
intraocular lymphoma
ocular neoplastic masquerade syndromes
uveal lymphoma
vitreoretinal lymphoma

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10.1080/09273948.2025.2548944

Cite this

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title = "Disease of the Year 2025: Uveitis Masquerade Syndromes Neoplastic Masquerades in Adults",

abstract = "Ocular neoplastic masquerade syndromes in adults pose a significant diagnostic challenge, as intraocular malignancies can closely mimic inflammatory ocular diseases. This review focuses on intraocular lymphoma, including vitreoretinal lymphoma and uveal lymphoma, and on choroidal metastases. It provides a comprehensive overview of disease epidemiology, symptoms, clinical manifestations, imaging findings, diagnostic approach, the role of ancillary testing, and current management strategies. The importance of a multidisciplinary approach is emphasized. This review aims to provide clinicians with practical tools for diagnosing and managing neoplastic masquerade syndromes.",

keywords = "Choroidal metastasis, intraocular lymphoma, ocular neoplastic masquerade syndromes, uveal lymphoma, vitreoretinal lymphoma",

author = "Zohar Habot-Wilner and Michael Ostrovsky and Ester Carre{\~n}o and \{Dom{\'i}nguez Garc{\'i}a\}, Laura and Sofia Androudi and Piergiorgio Neri and Sarah Touhami and Ines Leal",

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year = "2026",

doi = "10.1080/09273948.2025.2548944",

language = "English",

volume = "34",

pages = "211--223",

journal = "Ocular Immunology and Inflammation",

issn = "0927-3948",

publisher = "Taylor and Francis Ltd.",

number = "2",

}

TY - JOUR

T1 - Disease of the Year 2025

T2 - Uveitis Masquerade Syndromes Neoplastic Masquerades in Adults

AU - Habot-Wilner, Zohar

AU - Ostrovsky, Michael

AU - Carreño, Ester

AU - Domínguez García, Laura

AU - Androudi, Sofia

AU - Neri, Piergiorgio

AU - Touhami, Sarah

AU - Leal, Ines

PY - 2026

Y1 - 2026

N2 - Ocular neoplastic masquerade syndromes in adults pose a significant diagnostic challenge, as intraocular malignancies can closely mimic inflammatory ocular diseases. This review focuses on intraocular lymphoma, including vitreoretinal lymphoma and uveal lymphoma, and on choroidal metastases. It provides a comprehensive overview of disease epidemiology, symptoms, clinical manifestations, imaging findings, diagnostic approach, the role of ancillary testing, and current management strategies. The importance of a multidisciplinary approach is emphasized. This review aims to provide clinicians with practical tools for diagnosing and managing neoplastic masquerade syndromes.

AB - Ocular neoplastic masquerade syndromes in adults pose a significant diagnostic challenge, as intraocular malignancies can closely mimic inflammatory ocular diseases. This review focuses on intraocular lymphoma, including vitreoretinal lymphoma and uveal lymphoma, and on choroidal metastases. It provides a comprehensive overview of disease epidemiology, symptoms, clinical manifestations, imaging findings, diagnostic approach, the role of ancillary testing, and current management strategies. The importance of a multidisciplinary approach is emphasized. This review aims to provide clinicians with practical tools for diagnosing and managing neoplastic masquerade syndromes.

KW - Choroidal metastasis

KW - intraocular lymphoma

KW - ocular neoplastic masquerade syndromes

KW - uveal lymphoma

KW - vitreoretinal lymphoma

UR - https://www.scopus.com/pages/publications/105013745639

U2 - 10.1080/09273948.2025.2548944

DO - 10.1080/09273948.2025.2548944

M3 - Review article

C2 - 40829812

AN - SCOPUS:105013745639

SN - 0927-3948

VL - 34

SP - 211

EP - 223

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

IS - 2

ER -

Disease of the Year 2025: Uveitis Masquerade Syndromes Neoplastic Masquerades in Adults

Abstract

UN SDGs

Keywords

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