De novo small cell neuroendocrine prostate cancer: An atypical case presentation

Yalda Rahmani; Yosra Abdul Hafez; Ammar Agha; M. Zaid Jarai; Nikos Mac Millan Basiliu; Elham Mahjoor Azad; Abdulmunem Alsadi; Kais Kotiesh; Mohammad Alhamad; Fariborz Bagheri

doi:10.1016/j.eucr.2025.102970

De novo small cell neuroendocrine prostate cancer: An atypical case presentation

Yalda Rahmani
, Yosra Abdul Hafez
, Ammar Agha
, M. Zaid Jarai
, Nikos Mac Millan Basiliu
, Elham Mahjoor Azad
, Abdulmunem Alsadi
, Kais Kotiesh
, Mohammad Alhamad
, Fariborz Bagheri

Rashid Hospital and Dubai Medical College
Dubai Hospital
Medcare Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

Small cell neuroendocrine carcinoma comprises less than 1 % of all prostate cancers. We report a case of a 62-year-old male who presented acutely with severe lower urinary tract symptoms (LUTS), including nocturia, but with normal prostate-specific antigen (PSA) levels. A tender, stony-hard prostate on digital rectal examination (DRE) led to prostate biopsy and imaging. The biopsy confirmed neuroendocrine carcinoma, and chemotherapy was initiated. This case emphasizes the atypical presentation of neuroendocrine prostate cancer with acute, severe LUTS and rapid progression, underscoring the potential for missed diagnoses when PSA levels are normal.

Original language	English
Article number	102970
Journal	Urology Case Reports
Volume	59
DOIs	https://doi.org/10.1016/j.eucr.2025.102970
State	Published - Mar 2025

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SDG 3 Good Health and Well-being

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10.1016/j.eucr.2025.102970

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title = "De novo small cell neuroendocrine prostate cancer: An atypical case presentation",

abstract = "Small cell neuroendocrine carcinoma comprises less than 1 \% of all prostate cancers. We report a case of a 62-year-old male who presented acutely with severe lower urinary tract symptoms (LUTS), including nocturia, but with normal prostate-specific antigen (PSA) levels. A tender, stony-hard prostate on digital rectal examination (DRE) led to prostate biopsy and imaging. The biopsy confirmed neuroendocrine carcinoma, and chemotherapy was initiated. This case emphasizes the atypical presentation of neuroendocrine prostate cancer with acute, severe LUTS and rapid progression, underscoring the potential for missed diagnoses when PSA levels are normal.",

author = "Yalda Rahmani and Hafez, \{Yosra Abdul\} and Ammar Agha and Jarai, \{M. Zaid\} and \{Millan Basiliu\}, \{Nikos Mac\} and Azad, \{Elham Mahjoor\} and Abdulmunem Alsadi and Kais Kotiesh and Mohammad Alhamad and Fariborz Bagheri",

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year = "2025",

month = mar,

doi = "10.1016/j.eucr.2025.102970",

language = "English",

volume = "59",

journal = "Urology Case Reports",

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TY - JOUR

T1 - De novo small cell neuroendocrine prostate cancer

T2 - An atypical case presentation

AU - Rahmani, Yalda

AU - Hafez, Yosra Abdul

AU - Agha, Ammar

AU - Jarai, M. Zaid

AU - Millan Basiliu, Nikos Mac

AU - Azad, Elham Mahjoor

AU - Alsadi, Abdulmunem

AU - Kotiesh, Kais

AU - Alhamad, Mohammad

AU - Bagheri, Fariborz

PY - 2025/3

Y1 - 2025/3

N2 - Small cell neuroendocrine carcinoma comprises less than 1 % of all prostate cancers. We report a case of a 62-year-old male who presented acutely with severe lower urinary tract symptoms (LUTS), including nocturia, but with normal prostate-specific antigen (PSA) levels. A tender, stony-hard prostate on digital rectal examination (DRE) led to prostate biopsy and imaging. The biopsy confirmed neuroendocrine carcinoma, and chemotherapy was initiated. This case emphasizes the atypical presentation of neuroendocrine prostate cancer with acute, severe LUTS and rapid progression, underscoring the potential for missed diagnoses when PSA levels are normal.

AB - Small cell neuroendocrine carcinoma comprises less than 1 % of all prostate cancers. We report a case of a 62-year-old male who presented acutely with severe lower urinary tract symptoms (LUTS), including nocturia, but with normal prostate-specific antigen (PSA) levels. A tender, stony-hard prostate on digital rectal examination (DRE) led to prostate biopsy and imaging. The biopsy confirmed neuroendocrine carcinoma, and chemotherapy was initiated. This case emphasizes the atypical presentation of neuroendocrine prostate cancer with acute, severe LUTS and rapid progression, underscoring the potential for missed diagnoses when PSA levels are normal.

UR - https://www.scopus.com/pages/publications/85217888593

U2 - 10.1016/j.eucr.2025.102970

DO - 10.1016/j.eucr.2025.102970

M3 - Article

AN - SCOPUS:85217888593

SN - 2214-4420

VL - 59

JO - Urology Case Reports

JF - Urology Case Reports

M1 - 102970

ER -

De novo small cell neuroendocrine prostate cancer: An atypical case presentation

Abstract

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