Chemokines and chemokine receptors during COVID-19 infection

Bariaa A. Khalil; Noha Mousaad Elemam; Azzam A. Maghazachi

doi:10.1016/j.csbj.2021.01.034

Chemokines and chemokine receptors during COVID-19 infection

University of Sharjah

Research output: Contribution to journal › Review article › peer-review

199 Scopus citations

Abstract

Chemokines are crucial inflammatory mediators needed during an immune response to clear pathogens. However, their excessive release is the main cause of hyperinflammation. In the recent COVID-19 outbreak, chemokines may be the direct cause of acute respiratory disease syndrome, a major complication leading to death in about 40% of severe cases. Several clinical investigations revealed that chemokines are directly involved in the different stages of SARS-CoV-2 infection. Here, we review the role of chemokines and their receptors in COVID-19 pathogenesis to better understand the disease immunopathology which may aid in developing possible therapeutic targets for the infection.

Original language	English
Pages (from-to)	976-988
Number of pages	13
Journal	Computational and Structural Biotechnology Journal
Volume	19
DOIs	https://doi.org/10.1016/j.csbj.2021.01.034
State	Published - Jan 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ARDS
COVID-19
Chemokine Receptors
Chemokines
Immunity
SARS-CoV-2

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10.1016/j.csbj.2021.01.034

Cite this

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title = "Chemokines and chemokine receptors during COVID-19 infection",

abstract = "Chemokines are crucial inflammatory mediators needed during an immune response to clear pathogens. However, their excessive release is the main cause of hyperinflammation. In the recent COVID-19 outbreak, chemokines may be the direct cause of acute respiratory disease syndrome, a major complication leading to death in about 40\% of severe cases. Several clinical investigations revealed that chemokines are directly involved in the different stages of SARS-CoV-2 infection. Here, we review the role of chemokines and their receptors in COVID-19 pathogenesis to better understand the disease immunopathology which may aid in developing possible therapeutic targets for the infection.",

keywords = "ARDS, COVID-19, Chemokine Receptors, Chemokines, Immunity, SARS-CoV-2",

author = "Khalil, \{Bariaa A.\} and Elemam, \{Noha Mousaad\} and Maghazachi, \{Azzam A.\}",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s)",

year = "2021",

month = jan,

doi = "10.1016/j.csbj.2021.01.034",

language = "English",

volume = "19",

pages = "976--988",

journal = "Computational and Structural Biotechnology Journal",

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T1 - Chemokines and chemokine receptors during COVID-19 infection

AU - Khalil, Bariaa A.

AU - Elemam, Noha Mousaad

AU - Maghazachi, Azzam A.

PY - 2021/1

Y1 - 2021/1

N2 - Chemokines are crucial inflammatory mediators needed during an immune response to clear pathogens. However, their excessive release is the main cause of hyperinflammation. In the recent COVID-19 outbreak, chemokines may be the direct cause of acute respiratory disease syndrome, a major complication leading to death in about 40% of severe cases. Several clinical investigations revealed that chemokines are directly involved in the different stages of SARS-CoV-2 infection. Here, we review the role of chemokines and their receptors in COVID-19 pathogenesis to better understand the disease immunopathology which may aid in developing possible therapeutic targets for the infection.

AB - Chemokines are crucial inflammatory mediators needed during an immune response to clear pathogens. However, their excessive release is the main cause of hyperinflammation. In the recent COVID-19 outbreak, chemokines may be the direct cause of acute respiratory disease syndrome, a major complication leading to death in about 40% of severe cases. Several clinical investigations revealed that chemokines are directly involved in the different stages of SARS-CoV-2 infection. Here, we review the role of chemokines and their receptors in COVID-19 pathogenesis to better understand the disease immunopathology which may aid in developing possible therapeutic targets for the infection.

KW - ARDS

KW - COVID-19

KW - Chemokine Receptors

KW - Chemokines

KW - Immunity

KW - SARS-CoV-2

UR - https://www.scopus.com/pages/publications/85100385818

U2 - 10.1016/j.csbj.2021.01.034

DO - 10.1016/j.csbj.2021.01.034

M3 - Review article

AN - SCOPUS:85100385818

SN - 2001-0370

VL - 19

SP - 976

EP - 988

JO - Computational and Structural Biotechnology Journal

JF - Computational and Structural Biotechnology Journal

ER -

Chemokines and chemokine receptors during COVID-19 infection

Abstract

UN SDGs

Keywords

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