Calcium signaling in the ventricular myocardium of the Goto-Kakizaki type 2 diabetic rat

L. Al Kury; M. Smail; M. A. Qureshi; V. Sydorenko; A. Shmygol; M. Oz; J. Singh; F. C. Howarth

doi:10.1155/2018/2974304

Calcium signaling in the ventricular myocardium of the Goto-Kakizaki type 2 diabetic rat

L. Al Kury
, M. Smail
, M. A. Qureshi
, V. Sydorenko
, A. Shmygol
, M. Oz
, J. Singh
, F. C. Howarth

United Arab Emirates University

Zayed University, Abu Dhabi Campus
NASU - Bogomoletz Institute of Physiology
Qatar University
University of Central Lancashire

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients' age and duration of diabetes. The cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not well understood. The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca²⁺ transport in the Goto-Kakizaki (GK) diabetic rat heart. The GK rat is a widely used nonobese, nonhypertensive genetic model of T2DM which is characterized by insulin resistance, elevated blood glucose, alterations in blood lipid profile, and cardiac dysfunction.

Original language	English
Article number	2974304
Journal	Journal of Diabetes Research
Volume	2018
DOIs	https://doi.org/10.1155/2018/2974304
State	Published - 2018

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title = "Calcium signaling in the ventricular myocardium of the Goto-Kakizaki type 2 diabetic rat",

abstract = "The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients' age and duration of diabetes. The cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not well understood. The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca2+ transport in the Goto-Kakizaki (GK) diabetic rat heart. The GK rat is a widely used nonobese, nonhypertensive genetic model of T2DM which is characterized by insulin resistance, elevated blood glucose, alterations in blood lipid profile, and cardiac dysfunction.",

author = "\{Al Kury\}, L. and M. Smail and Qureshi, \{M. A.\} and V. Sydorenko and A. Shmygol and M. Oz and J. Singh and Howarth, \{F. C.\}",

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year = "2018",

doi = "10.1155/2018/2974304",

language = "English",

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journal = "Journal of Diabetes Research",

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T1 - Calcium signaling in the ventricular myocardium of the Goto-Kakizaki type 2 diabetic rat

AU - Al Kury, L.

AU - Smail, M.

AU - Qureshi, M. A.

AU - Sydorenko, V.

AU - Shmygol, A.

AU - Oz, M.

AU - Singh, J.

AU - Howarth, F. C.

PY - 2018

Y1 - 2018

N2 - The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients' age and duration of diabetes. The cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not well understood. The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca2+ transport in the Goto-Kakizaki (GK) diabetic rat heart. The GK rat is a widely used nonobese, nonhypertensive genetic model of T2DM which is characterized by insulin resistance, elevated blood glucose, alterations in blood lipid profile, and cardiac dysfunction.

AB - The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients' age and duration of diabetes. The cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not well understood. The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca2+ transport in the Goto-Kakizaki (GK) diabetic rat heart. The GK rat is a widely used nonobese, nonhypertensive genetic model of T2DM which is characterized by insulin resistance, elevated blood glucose, alterations in blood lipid profile, and cardiac dysfunction.

UR - https://www.scopus.com/pages/publications/85054740012

U2 - 10.1155/2018/2974304

DO - 10.1155/2018/2974304

M3 - Review article

C2 - 29850600

AN - SCOPUS:85054740012

SN - 2314-6745

VL - 2018

JO - Journal of Diabetes Research

JF - Journal of Diabetes Research

M1 - 2974304

ER -

Calcium signaling in the ventricular myocardium of the Goto-Kakizaki type 2 diabetic rat

Abstract

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