Biophysical properties of dynein in vivo

George T. Shubeita; Babu J.N. Reddy; Steven P. Gross

doi:10.1016/B978-0-12-809470-9.00006-0

Biophysical properties of dynein in vivo

George T. Shubeita
, Babu J.N. Reddy
, Steven P. Gross

New York University Abu Dhabi

University of California at Irvine

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

This chapter discusses what is known about dynein function in vivo, especially with regards to biophysical properties such as force production, velocity and travel distances, and also how such functions are regulated. Dynein frequently works in ensembles, e.g. with multiple motors and co-factors working together to transport a cargo. The chapter discusses how regulation that directly targets single-molecule properties ultimately alters ensemble function.

Original language	English
Title of host publication	Dyneins
Subtitle of host publication	Dynein Mechanics, Dysfunction, and Disease: Second Edition
Publisher	Elsevier
Pages	136-151
Number of pages	16
Volume	2
ISBN (Electronic)	9780128097014
ISBN (Print)	9780128094709
DOIs	https://doi.org/10.1016/B978-0-12-809470-9.00006-0
State	Published - 28 Nov 2017

Keywords

Dynactin
Dynein
Group function
Lis1
Multiple motors
NudE

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10.1016/B978-0-12-809470-9.00006-0

Cite this

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KW - Group function

KW - Lis1

KW - Multiple motors

KW - NudE

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ER -

Biophysical properties of dynein in vivo

Abstract

Keywords

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