Bariatric Surgery Improves Serum CD40L Levels as a Predictor of Cardiovascular Risk: Systematic Review and Meta-analysis

Tannaz Jamialahamdi; Ali H. Eid; Ninh T. Nguyen; Kishore M. Gadde; Vasily N. Sukhorukov; Wael Almahmeed; Matthew Kroh; Amirhossein Sahebkar

doi:10.1007/s11695-024-07210-8

Bariatric Surgery Improves Serum CD40L Levels as a Predictor of Cardiovascular Risk: Systematic Review and Meta-analysis

Tannaz Jamialahamdi
, Ali H. Eid
, Ninh T. Nguyen
, Kishore M. Gadde
, Vasily N. Sukhorukov
, Wael Almahmeed
, Matthew Kroh
, Amirhossein Sahebkar

Cleveland Clinic Abu Dhabi

Mashhad University of Medical Sciences
Qatar University
University of California at Irvine
Russian Academy of Medical Sciences
Petrovsky National Research Centre of Surgery
Cleveland Clinic Foundation
Saveetha Institute of Medical and Technical Sciences (Deemed to be University)

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

CD40 and its ligand have been recently implicated in the pathogenesis of cardiovascular disease (CVD). This meta-analysis examined the effect of bariatric surgery in reducing circulating CD40L levels. A systematic review was performed using Embase, Google Scholar, PubMed, Scopus, and Web of Science. The meta-analysis was provided by Comprehensive Meta-Analysis (CMA) V4 software. The overall effect size was detected by a random-effects meta-analysis and the leave-one-out approach. Random-effects meta-analysis of 7 studies including 191 subjects showed a significant reduction in CD40L after bariatric surgery (standardized mean difference (SMD), − 0.531; 95% CI, − 0.981, − 0.082; p = 0.021; I², 87.00). Circulating levels of CD40L are decreased after bariatric surgery which may represent a mechanism for improvement of metabolic profile.

Original language	English
Pages (from-to)	1929-1937
Number of pages	9
Journal	Obesity Surgery
Volume	34
Issue number	5
DOIs	https://doi.org/10.1007/s11695-024-07210-8
State	Published - May 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CD40L
Immune system
Inflammation
Metabolic bariatric surgery
Weight loss

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10.1007/s11695-024-07210-8

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title = "Bariatric Surgery Improves Serum CD40L Levels as a Predictor of Cardiovascular Risk: Systematic Review and Meta-analysis",

abstract = "CD40 and its ligand have been recently implicated in the pathogenesis of cardiovascular disease (CVD). This meta-analysis examined the effect of bariatric surgery in reducing circulating CD40L levels. A systematic review was performed using Embase, Google Scholar, PubMed, Scopus, and Web of Science. The meta-analysis was provided by Comprehensive Meta-Analysis (CMA) V4 software. The overall effect size was detected by a random-effects meta-analysis and the leave-one-out approach. Random-effects meta-analysis of 7 studies including 191 subjects showed a significant reduction in CD40L after bariatric surgery (standardized mean difference (SMD), − 0.531; 95\% CI, − 0.981, − 0.082; p = 0.021; I2, 87.00). Circulating levels of CD40L are decreased after bariatric surgery which may represent a mechanism for improvement of metabolic profile.",

keywords = "CD40L, Immune system, Inflammation, Metabolic bariatric surgery, Weight loss",

author = "Tannaz Jamialahamdi and Eid, \{Ali H.\} and Nguyen, \{Ninh T.\} and Gadde, \{Kishore M.\} and Sukhorukov, \{Vasily N.\} and Wael Almahmeed and Matthew Kroh and Amirhossein Sahebkar",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.",

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doi = "10.1007/s11695-024-07210-8",

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T2 - Systematic Review and Meta-analysis

AU - Jamialahamdi, Tannaz

AU - Eid, Ali H.

AU - Nguyen, Ninh T.

AU - Gadde, Kishore M.

AU - Sukhorukov, Vasily N.

AU - Almahmeed, Wael

AU - Kroh, Matthew

AU - Sahebkar, Amirhossein

N1 - Publisher Copyright: © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.

PY - 2024/5

Y1 - 2024/5

N2 - CD40 and its ligand have been recently implicated in the pathogenesis of cardiovascular disease (CVD). This meta-analysis examined the effect of bariatric surgery in reducing circulating CD40L levels. A systematic review was performed using Embase, Google Scholar, PubMed, Scopus, and Web of Science. The meta-analysis was provided by Comprehensive Meta-Analysis (CMA) V4 software. The overall effect size was detected by a random-effects meta-analysis and the leave-one-out approach. Random-effects meta-analysis of 7 studies including 191 subjects showed a significant reduction in CD40L after bariatric surgery (standardized mean difference (SMD), − 0.531; 95% CI, − 0.981, − 0.082; p = 0.021; I2, 87.00). Circulating levels of CD40L are decreased after bariatric surgery which may represent a mechanism for improvement of metabolic profile.

AB - CD40 and its ligand have been recently implicated in the pathogenesis of cardiovascular disease (CVD). This meta-analysis examined the effect of bariatric surgery in reducing circulating CD40L levels. A systematic review was performed using Embase, Google Scholar, PubMed, Scopus, and Web of Science. The meta-analysis was provided by Comprehensive Meta-Analysis (CMA) V4 software. The overall effect size was detected by a random-effects meta-analysis and the leave-one-out approach. Random-effects meta-analysis of 7 studies including 191 subjects showed a significant reduction in CD40L after bariatric surgery (standardized mean difference (SMD), − 0.531; 95% CI, − 0.981, − 0.082; p = 0.021; I2, 87.00). Circulating levels of CD40L are decreased after bariatric surgery which may represent a mechanism for improvement of metabolic profile.

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KW - Inflammation

KW - Metabolic bariatric surgery

KW - Weight loss

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DO - 10.1007/s11695-024-07210-8

M3 - Review article

C2 - 38578522

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SN - 0960-8923

VL - 34

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JF - Obesity Surgery

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ER -

Bariatric Surgery Improves Serum CD40L Levels as a Predictor of Cardiovascular Risk: Systematic Review and Meta-analysis

Abstract

UN SDGs

Keywords

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